Theoretical study of a potential low-noise semimetal-basedavalanche photodetector

The authors present a theoretical analysis of a possible avalanching photodetector (APD)-based on II-VI compound semiconductors. Each unit cell is composed of a HgTe layer, or a similar semimetal, sandwiched between two layers of CdTe and HgCdTe or similar semiconducting materials. The barrier layers are graded so that the leading barrier height is just high enough to eliminate the thermionic emission dark current out of the well. The use of a semimetal within the well has a distinct advantage over a semiconductor, which is that the ionization process is essentially an interband mechanism since the confined carriers within the well lie within the overlapping conduction and valence bands. As a result, the concentration of target carriers is virtually inexhaustible as in a conventional interband device     

Almost k-wise independence versus k-wise independence

We say that a distribution over {0,1}ⁿ is (ε,k)-wise independent if its restriction to every k coordinates results in a distribution that is ε-close to the uniform distribution. A natural question regarding (ε,k)-wise independent distributions is how close they are to some k-wise independent distribution. We show that there exist (ε,k)-wise independent distributions whose statistical distance is at least n^O(k)·ε from any k-wise independent distribution. In addition, we show that for any (ε,k)-wise independent distribution there exists some k-wise independent distribution, whose statistical distance is n^O(k)·ε.     

Measurement of photon beam backscatter from collimators to the beam monitor chamber using target-current-pulse-counting and telescope techniques

Backscattered radiation (BSR) arising from field-defining collimators and entering the beam monitor chamber (BMC) may contribute to observed variations in medical linear accelerator photon beam output with collimator setting. Measuring the magnitude of such contributions for particular accelerators under specified operating conditions is therefore important when attempting to understand and model accelerator head scatter. The present work was conducted to confirm some backscatter measurements for collimating jaws reported previously and to extend these to include other accelerators and a multileaf collimator (MLC). BSR reaching the BMC from the jaws of Clinac 600C, 2100C and 2300CD accelerators and from an MLC on the 2300CD was investigated using both target-current-pulse-counting and telescope methods. Our measurements show that for the Clinac 600C BSR-dependent output variations are negligible. However, for the 2100C and 2300CD BSR-dependent relative output increased in an almost linear fashion, by up to 2.4% for 15 and 18 MV beams, and by up to 1.7% for 6 MV beams, as the field size varied from 5 x 5 cm2 to 40 x 40 cm2. The magnitude of BSR dependent upon collimator location in the head, as expected, thereby contributing to the collimator exchange effect. An earlier study at our centre using the telescope method had reported higher BSR levels. This discrepancy was resolved when corrections for telescope block and room scatter, previously assumed negligible, were made.     

Cost estimation of structural skeleton using an interactive automation algorithm: A conceptual approach

This paper addresses a new concept for generating bills of quantities (B.o.Qs) using AutoCAD drawings for a building project, which demonstrates the application of Industry Foundation Class (IFC), developed by International Alliance for Interoperability (IAI). The procedure considers types of materials and the structural shapes of the AutoCAD drawings to compute the cost of the structural skeleton elements using interactive automation. The main concept focuses on using layer computation of the AutoCAD drawing after converting it into a drawing inter-exchangeable file format (DXF). Once the coordinates are detected, it is easier to determine the area and volume for any structural shape, including circles and polygons. The extracting method is a new technique for structural engineers and quantity surveyors to estimate required material for beam, columns, slabs and foundations. The algorithm extracts and recognizes the layers and objects from a two dimensional DXF drawing along with the coordinates information. The results obtained using this technique are more accurate and reliable than manual procedures or any other traditional techniques. In this paper, an automated and interactive procedure for B.o.Q computation is demonstrated. The process involves a user-friendly interface, dynamic linking to the structural drawings and tracking of B.o.Q modifications at the same time.     

Comparison of two different approaches for making design sensitivity analysis an integrated part of finite element analysis

This paper presents a comparison of two approaches for incorporating design sensitivity calculations into finite element analysis. The formulations depend on the implicit differentiation method and require few additional calculations to obtain the design sensitivity derivatives. The first approach by-passes the direct calculation of the stiffness matrix derivatives by calculating the sensitivity derivatives at the stress recovery stage of the analysis. The second approach depends on the direct calculation of the derivatives of the stiffness matrix, which are stored for re-use in multiple load case analyses, and subsequent matrix multiplications to evaluate the design sensitivities. The two approaches are developed and implemented to calculate the design sensitivities for continuum and structural isoparametric elements. In addition, a criterion is developed to aid in deciding which approach is better for a given number of load cases. To demonstrate the validity of the developed criterion and to evaluate the relative merits of each approach, some sensitivity calculation test problems are solved with different numbers of load cases.     

Expression and cellular distribution of baculovirus-expressed bovine herpesvirus 1 (BHV-1) glycoprotein D (gD) sequences

Glycoprotein D (gD) of bovine herpesvirus 1 (BHV-1), a homolog of herpes simplex virus gD, represents a major component of the viral envelope and is a dominant immunogen. To study the antigenic properties of the different regions of gD, we have expressed the full-length gD encoding gene and overlapping fragments spanning various regions of the gD open reading frame in a baculovirus (Autographa californica nuclear polyhedrosis virus)--insect cell (Spodoptera frugiperda, SF-9) system. Maximum levels of expression for all proteins were obtained 48 to 72 h post infection of SF-9 cells by recombinant viruses. Full-length and truncated recombinant gD proteins reacted specifically with anti-gD monospecific serum as determined by immunoprecipitation and immunoblotting, indicating that the proteins retained their antigenicity. However, based on the reactivity with a panel of gD-specific monoclonal antibodies (Mabs), the full-length recombinant gD lacked proper expression for two highly neutralizing linear epitopes identified by Mabs R54 and 9D6. The rest of the epitopes appeared to be preserved and antigenically unaltered. Immunofluorescence studies of recombinant baculovirus infected SF-9 cells using gD monospecific serum, revealed no direct correlation between cellular localization of the expressed proteins and their amino acid sequences.     

Fuzzy reliability analysis of nanocomposite ZnO beams using hybrid analytical-intelligent method

A hybrid analytical-intelligent approach is proposed for fuzzy reliability analysis of the composite beams reinforced by zinc oxide (ZnO) nanoparticle. The fuzzy reliability index corresponding to buckling failure mode of nanocomposite beam under thickness-direction external voltage is computed based on three-levels: (1) fuzzy analysis, (2) reliability analysis and (3) analytical buckling analysis. In fuzzy analysis level, an improved gravitational search algorithm has been applied to determine uncertainty interval for membership levels of reliability index. The adaptive formulation with a dynamical self-adjusting process is used for reliability analysis level based on conjugate first-order reliability method (FORM). The self-adjusting term in conjugate sensitivity vector is used to satisfy the sufficient descent condition for controlling instability of FORM formula while the proposed conjugate scalar factor is computed less than the original conjugate FORM, thus it may be provided with the efficient results for the convex problem. The new and previous sensitivity vectors obtained by conjugate and steepest descent vectors dynamically adjusted the proposed conjugate factor. In the buckling analysis level, an exponential theory in conjunction with the method of energy is utilized. Fuzzy random variables including applied voltage, the volume fraction of ZnO, thickness of beam, spring constant and shear constant of the foundation are considered in studied nanocomposite beam. Survey results indicated that the proposed method can provide stable and acceptable fuzzy membership functions for parametric study. Moreover, the ratio of length to thickness and spring constant of foundation are the more sensitive parameters which affect fuzzy reliability index significantly.

     

Modern Template Design and Biological Evaluation of Cephradine-loaded Magnesium Calcium Silicate Nanocomposites as an Inhibitor for Nosocomial Bacteria in Biomedical Applications

Silicon - Magnesium calcium silicate nanostructures (MCSNS) loaded with (0.0, 0.6, 0.9, and 1.2 wt%) of Cephradine-drug consisting of mesoporous particles were functionally prepared by sol-gel...     

X-ray Fluorescence Uptake Measurement of Functionalized Gold Nanoparticles in Tumor Cell Microsamples

Quantitative cellular in vitro nanoparticle uptake measurements are possible with a large number of different techniques, however, all have their respective restrictions. Here, we demonstrate the application of synchrotron-based X-ray fluorescence imaging (XFI) on prostate tumor cells, which have internalized differently functionalized gold nanoparticles. Total nanoparticle uptake on the order of a few hundred picograms could be conveniently observed with microsamples consisting of only a few hundreds of cells. A comparison with mass spectroscopy quantification is provided, experimental results are both supported and sensitivity limits of this XFI approach extrapolated by Monte-Carlo simulations, yielding a minimum detectable nanoparticle mass of just 5 pg. This study demonstrates the high sensitivity level of XFI, allowing non-destructive uptake measurements with very small microsamples within just seconds of irradiation time.     

Preparation,Properties and Applications of the Hybrid Organic/Inorganic Nanocomposite Based on Nanoporous Carbon Matrix

Journal of Inorganic and Organometallic Polymers and Materials - Nanoporous carbon matrix was prepared by the sol–gel process from pyrogallol-formaldehyde (PF) mixtures in water using picric...